Oaxaca de Juárez is part of the site recognized by UNESCO as the Historic Center of Oaxaca and the archaeological site of Monte Albán, inscribed on the World Heritage List in 1987. UNESCO highlights both the archaeological heritage of Monte Albán and the city's remarkable urban grid.

The Historic Center is home to buildings spanning diverse architectural styles. INAH notes expressions of Baroque, Churrigueresque, Classic, and 19th-century French Neoclassical architecture.

One of the city's cultural landmarks is the former convent of Santo Domingo de Guzmán, which currently houses the Museum of Oaxacan Cultures. The complex is also connected to the renowned Ethnobotanical Garden of Oaxaca.

The city can also be experienced through its vibrant traditional markets, where authentic culinary specialties and local ingredients abound. These spaces offer an intimate way to connect with local culture and the everyday rhythm of Oaxaca de Juárez.